Molecular oxygen diffusion in a capillary microenvironment during Photodynamic Therapy
by Gemunu S. Happawana; Amaranath Premasiri
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 7, No. 1, 2011

Abstract: Tumour destruction due to Photodynamic Therapy (PDT) is mainly governed by the amount of molecular oxygen present in the tumour. Continuous and effective treatment is based on the availability of a constant level of molecular oxygen. Oxygen is one of the rate-limiting factors in PDT. In this paper an analytical model with the specific features of tissue micro-vascular environment to represent the molecular oxygen diffusion patterns in a capillary bed during the PDT is developed. A thorough understanding of molecular oxygen diffusion in the capillary bed facilitates in defining the dosage required during applications of PDT.

Online publication date: Wed, 21-Jan-2015

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