Units, weights and concentrations: the botulinum toxin dilemma
by Andrew Pickett
The Botulinum J. (TBJ), Vol. 2, No. 1, 2011

Abstract: Over the years, scientists have worked with BoNT as crude and purified complexes, both in solution or crystalline. They have also used purified neurotoxins, again in solution or crystalline, either as true crystals or so-called 'crystalline' precipitates from purifications with ammonium sulphate fractionations. They use protein concentration measured by one of several methods, LD50 units measured by one of several methods and now also concentration itself, expressed in molarity to describe the quantities they use. There are even signs that extinction coefficients are starting to appear in the literature. However, the community of BoNT scientists is not good at indicating what their measurements refer to when they cite these values. That is the dilemma briefly discussed in this commentary.

Online publication date: Sat, 06-Aug-2011

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the The Botulinum J. (TBJ):
Login with your Inderscience username and password:

    Username:        Password:         

Forgotten your password?


Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com