An energy-based technique for the development of a mechanobiological growth model of vertebrae
by Hui Lin, Meiqing Wang
International Journal of Experimental and Computational Biomechanics (IJECB), Vol. 1, No. 4, 2011

Abstract: Mechanobiological growth is the biological process whereby bone growth is modulated by mechanical loading. The goal of this study is to develop an energy-based mechanobiological bone growth model. Mechanobiological procedures basically include mechanosensing and mechanoregulation. This study represented the mechanosensing as a mathematical model combining energy and mechanical-triggered deformation. The mechanoregulation was modelled as a mathematical form integrated distortion and dilatation energy. Mechanobiological growth model was developed from those two procedures and represented as a function of distortion and dilatation stresses. The model was tested by using finite element model of a thoracic vertebra (T7) for simulating one-year growth procedure under multi-axial loads. The simulation results presented the retarded and stimulated growth under compression and tension. Shear stress increased the growth rate with 20%-40%. This model agreed with experimental study of growth and published numerical growth simulation of human vertebrae as well as mechanobiology theory. This model allows simulating vertebral growth under multi-direction loads.

Online publication date: Tue, 30-Dec-2014

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