Simultaneous or sequential administration of botulinum neurotoxin E does not reduce the duration of paralysis caused by botulinum neurotoxin A in rat EDL muscle
by Michael Adler, Sharad S. Deshpande, James P. Apland
The Botulinum J. (TBJ), Vol. 1, No. 4, 2010

Abstract: Exposure to botulinum neurotoxin serotype A (BoNT/A) or serotype E (BoNT/E) results in muscle paralysis owing to cleavage of the SNARE protein SNAP-25 between residues 197-198 or 180-181, respectively. Although SNAP-25 is the substrate for both serotypes, the duration of paralysis is considerably longer for muscles exposed to BoNT/A. This study was designed to determine whether paralysis times were determined by differences in the half-lives of the truncated SNAP-25 fragments or by differences in the persistence of the respective BoNT light chain (LC) within the nerve terminals.

Online publication date: Thu, 17-Mar-2011

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