The inveterate botulinum neurotoxin A ushers in exo-endocytic crypts
by Joseph G. Potian, Vishwendra Patel, Joseph J. McArdle, Baskaran Thyagarajan
The Botulinum J. (TBJ), Vol. 1, No. 4, 2010

Abstract: Botulinum neurotoxins (BoNTs), serotypes A through G (BoNT/A to BoNT/G) are potential bioweapons and are extensively used clinically. Although the mechanism of BoNT/A cleavage of SNAP25 is well characterised, little is known regarding the uptake of BoNT/A at the Motor Nerve Terminal (MNT). We demonstrate that BoNT/A uses Clathrin Coated Pit (CCP) dependent mechanisms for endocytosis and that disruption of CCP reduces BoNT/A uptake into mouse MNTs and Neuro 2a cells. This presents a novel strategy for protection against BoNT/A. Our data stimulate the exploration of BoNT/A – interactome signalling for the development of prophylactics as well as therapeutics against botulism.

Online publication date: Thu, 17-Mar-2011

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