Influence of X-ray and/or CpG-DNA induced oxidative stress on adaptive response in human lymphocytes
by Marina S. Konkova, Aleksei V. Ermakov, Liudmila V. Efremova, Svetlana V. Kostyuk, Natalya N. Veiko
International Journal of Low Radiation (IJLR), Vol. 7, No. 6, 2010

Abstract: Peripheral blood lymphocytes of apparently healthy donors were exposed to low-dose ionising radiation and/or human-genome CpG-DNA fragments accumulating in total extracellular DNA. Both factors administered separately appeared to induce transposition of the 1q12 loci of homologous chromosomes in lymphocytes from the pericentromeric region towards the centre of the nucleus; they were also shown to activate rRNA synthesis, to stimulate activation of caspase-3 activity and to increase amounts of the TLR9 and MyD88 mRNAs. However, upon simultaneous exposure to X-ray radiation and CpG-DNA, all the reactions mentioned above failed to develop in the cells. Practical aspects of the revealed phenomenon are discussed in this paper.

Online publication date: Thu, 23-Dec-2010

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