Structure prediction and antigenic site determination of CD4 antigen
by Arun G. Ingale
International Journal of Medical Engineering and Informatics (IJMEI), Vol. 2, No. 3, 2010

Abstract: CD antigen are playing vital role in many diseases. The human CD4 molecule binds both human immunodeficiency virus (HIV) envelope protein gp120 and class II major histocompatibility complex (MHC) molecules. This binding help for the internalisation of HIV and its replication in host CD4 T-cells concentration fall drastically, a disastrous fall in CD4 T-cells destroy cell immediate defence and leaves the patients open to life threatening infection through opportunistic organism such as Pnemoastic carinii and cytomegalovirus. In the present investigation attempts have been made to study the structural and molecular aspects of CD4. To illustrate the stability of electrostatic representation, the solvent-accessible surface of the molecules was calculated using the Deepveiw or Swisspdb package. Two large positive and two large negative potential patches characterise the surface of the antigen in this system. One interesting feature of the CD4 interface is the high number of side chain residue. Energy minimisation analysis results showed the bond energy 550.838 KJ/mol, angle 1,176.970 KJ/mol, torsion 2,205.20 KJ/mol, non-bonded -9,726.67 KJ/mol, electrostatic-10,237.85 KJ/mol and improper 465.336 KJ/mol.

Online publication date: Tue, 14-Sep-2010

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Medical Engineering and Informatics (IJMEI):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com