High resolution read-out circuit for DNA label-free detection system
by Daniela De Venuto, Bruno Ricco
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 4, No. 3, 2010

Abstract: This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridisation effect is monitored by means of a Charge Sensitive Amplifier (CSA) and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors.

Online publication date: Tue, 31-Aug-2010

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