The response of peripheral blood mononuclear cells to shape memory alloys
by Rebeka Rudolf, Kambiz Mehrabi, Albert C. Kneissl, Mihael Bruncko, Ivan Anzel, Sergej Tomic, Tanja Dzopalic, Miodrag Colic
International Journal of Immunological Studies (IJIS), Vol. 1, No. 2, 2010

Abstract: The aim of this work was to study the response of human peripheral blood mononuclear cells (PB-MNCs) to Cu-Al-Ni and Ni-Ti shape memory alloys (SMAs). The alloys were prepared as rapidly solidified thin ribbons via melt spinning. It has been shown that the ribbons were non cytotoxic for PB-MNCs as determined by the viability and apoptosis assay. In 18 cultures out of 20 cultures of individual donor PB-MNCs cultivated with Cu-Al-Ni SMAs, no significant changes in the production of Th1 (IFN-γ), Th2 (IL-5 and IL-10) and proinflammatory (IL-1ß, TNF-α, IL-6 and IL-8) cytokines were detected compared to controls. In two cultures out of 20, a significant increase in the production of Th1 and proinflammatory cytokines was observed. Microstructural analyses confirmed the formation of thin oxide on the surface of both SMA ribbons.

Online publication date: Mon, 30-Aug-2010

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