Development of nanostructured lipid carriers (NLC) for controlled delivery of meloxicam
by S. Khurana, P.M.S. Bedi, N.K. Jain
International Journal of Biomedical Nanoscience and Nanotechnology (IJBNN), Vol. 1, No. 2/3/4, 2010

Abstract: Nanostructured lipid carriers (NLC) are becoming increasingly popular due to their obvious advantages over other existing lipid based carriers. They have improved drug encapsulation efficiency and have an ability to reduce drug leakage during storage. The main objective of this study is to develop aqueous dispersions of NLC for the delivery of meloxicam (ME). ME-NLC dispersions were prepared by microemulsion template strategy and characterised for size, polydispersity, zeta potential, drug entrapment efficiency, occlusivity index, and release kinetics. Solid lipid nanoparticles (SLN) and nanoemulsion (NE) were prepared for comparison. The NLC and SLN showed faster onset of action followed by sustained release due to biphasic release pattern in comparison to the constant release from NE. Compared to NE and SLN, the excellent physical stability of NLC dispersions against drug leakage was seen. NLC showed significant occlusion effect that makes them suitable for topical use.

Online publication date: Fri, 13-Aug-2010

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Biomedical Nanoscience and Nanotechnology (IJBNN):
Login with your Inderscience username and password:

    Username:        Password:         

Forgotten your password?


Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com