On a novel coalescent model for genome-wide evolution of Copy Number Variations
by Antonina Mitrofanova, Bhubaneswar (Bud) Mishra
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 4, No. 3, 2010

Abstract: Since we are limited in our knowledge of human demographic history and variations of recombination and mutation rates, large-scale computer simulation is a necessary tool in genetics. Here we propose and computationally simulate a model of evolution for unique and segmentally duplicated regions of human genome. Since such segmentally duplicated regions show a complex behaviour of copy number changes, our model will hopefully lead to a better understanding of the evolutionary developments of CNVs, algorithms for associations studies with CNV markers, and finally, for characterising parameters for stochastic diffusion models, describing asymptotic behaviour of evolutionary processes.

Online publication date: Wed, 02-Jun-2010

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