A new approach to individual prognostication of cancer development under conditions of chronic radiation exposure
by G.A. Veremeyeva, I.V. Akushevich, S.V. Ukraintseva, A.I. Yashin, S.B. Epifanova, E.A. Blinova, A.V. Akleyev
International Journal of Low Radiation (IJLR), Vol. 7, No. 1, 2010

Abstract: This paper describes a new approach to modelling carcinogenesis, including that induced by ionising radiation. The specific feature of the developed approach is that the model, still adhering to the mutational theory of carcinogenesis, includes parameters of intracellular processes which can be measured for any individual. The assumptions laying the basis for this approach are that cell malignisation results from inefficient functioning of a number of barrier mechanisms on the cell's way from the primary DNA damage to phenotypically manifested mutation/aberration initiating or promoting carcinogenesis, and inefficient functioning of the barrier mechanisms is caused, in turn, by one or several genetic and/or epigenetic events, the number and type of which are of no importance for this approach. The paper points out the necessity and possibility to include model parameters that reflect the status of such intercellular mechanisms as the system of antioxidant protection, repair and apoptosis. The theoretical formalism of the model structure is presented as the generalisation of the concepts of multiple-stage and multiple-pathway models for describing the new biological approach to modelling. Also, the paper discusses issues such as schemes for measuring the parameters included in the model, approaches to individual risk estimation and further generalisation of the model.

Online publication date: Tue, 20-Apr-2010

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Low Radiation (IJLR):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com