Cross-platform microarray data integration using the Normalised Linear Transform Online publication date: Thu, 11-Mar-2010
by Huilin Xiong, Ya Zhang, Xue-Wen Chen, Jiangsheng Yu
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 4, No. 2, 2010
Abstract: Small sample size is one of the biggest challenges in microarray data analysis. With microarray data being dramatically accumulated, integrating data from related studies represents a natural way to increase sample size so that more reliable statistical analysis may be performed. In this paper, we present a simple and effective integration scheme, called Normalised Linear Transform (NLT), to combine data from different microarray platforms. The NLT scheme is compared with three other integration schemes for two tasks: classification analysis and gene marker selection. Our experiments demonstrate that the NLT scheme performs best in terms of classification accuracy, and leads to more biologically significant marker genes.
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