Labelling of albumin microspheres with ¹⁸⁸Re: a possible agent for radiotherapy
by Virginia Nazarica Borza, Elena Neacsu, Catalina Mihaela Barna, Nicoleta Popescu-Pogrion, Ionel Mercioniu, Cristina Lavinia Nistor
International Journal of Nano and Biomaterials (IJNBM), Vol. 2, No. 6, 2009

Abstract: Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter ¹⁸⁸Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was studied. Under optimised conditions, after 60 min reaction time, at 95°C, the reaction yield was more than 95%. Labelled microspheres were found to be stable in vitro; 43 h after labelling, 87% of ¹⁸⁸Re was bound to the microspheres.

Online publication date: Wed, 16-Sep-2009

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