L-Asparagine on strontium hydroxyapatite nanorods morphology and biocompatibility
by Raymond Wing Moon Lam, Chi Tak Wong, Zhao Yang Li, Keith Dip Kei Luk, Kenneth M.C. Cheung, Peter Kwong Yuen Chiu, Bing Xu, Wai Kin Chan, David Fang, John C.Y. Leong, William Weijia Lu
International Journal of Biomedical Engineering and Technology (IJBET), Vol. 2, No. 4, 2009

Abstract: In this study, we investigated the influence of L-Asparagine (L-Asn) on strontium hydroxyapatite (Sr-HA) nanorod morphology and their biocompatibility. Ammonia was used to adjust the pH of L-Asn Sr-HA precursor and was heated at 80-120°C for 5-15 h. From Transmission Electron Microscopy's (TEM) images, the lengths and diameters of the nanorod were 0.3901 ± 0.0804 µm and 30.4 ± 4.6 nm, respectively. L-Asn Sr-HA phosphate system provides a high phase purity of monodispersed strontium hydroxyapatite nanorod. From Live/Dead Assay, L-Asn Sr-HA nanorod showed cell-dependent cytotoxicity (SaOS-2 < C2C12 < L929) and these results have shown L-Asn Sr-HA nanorod can be adopted as fibrous tissue formation inhibitor.

Online publication date: Tue, 11-Aug-2009

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