Comparative study for brain delivery of tacrine using polysorbate 80-coated poly(butylcyanoacrylate) and pegylated-poly(butylcyanoacrylate) nanoparticles
by Basel A. Abdel-Wahab, Mohamed M. Abdel-Latif, Atef A. Abdel-Hafez
International Journal of Nano and Biomaterials (IJNBM), Vol. 2, No. 1/2/3/4/5, 2009

Abstract: Many studies indicated that polysorbate (PS) 80-coated polybutylcyanoacrylate (PBCA) nanoparticles can deliver drugs that poorly penetrate BBB to the brain. Also, the polyethylene glycolated-polybutylcyanoacrylate (PEG-PBCA) nanoparticles have a good safety profiles and sustained drug release. The purpose of this study is to compare between the ability of both PS80-coated PBCA nanoparticles and PEG-PBCA nanoparticles in targeting of tacrine to the brain. Rats treated with tacrine intravenously in three forms: 1) simple solution; 2) loaded on PS80-coated PBCA nanoparticles; 3) loaded on PEG-PBCA nanoparticles. Tacrine antiamnesic effect was tested using the passive avoidance reflex (PAR) test. Also tacrine concentrations in brain and liver were measured using HPLC. Results demonstrated that, both PS-80 coated and PEG-PBCA nanoparticles successfully enhanced brain delivery of tacrine in rats while PEG-PBCA nanoparticles have higher brain targeting ability and less liability to be up taken by the liver, this provides it more safety and longer duration.

Online publication date: Sat, 08-Aug-2009

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