Evaluation of toosendanin as a botulinum neurotoxin antagonist
by Michael Adler, James D. Nicholson
The Botulinum J. (TBJ), Vol. 1, No. 2, 2008

Abstract: Toosendanin (TSN), a tetranortriterpenoid compound from the plant Melia toosendan, has been reported to protect rats and non-human primates from the lethal actions of botulinum neurotoxin A (BoNT/A). TSN was tested in isolated mouse phrenic nerve-hemidiaphragm preparations against BoNT serotypes A, B and E. When added prior to toxin, TSN was found to delay the onset of muscle paralysis with all 3 BoNT serotypes. TSN had little or no effect on BoNT-induced muscle paralysis when applied 30 min after BoNT. It is suggested that the antagonist activity of TSN may result from inhibition of BoNT translocation.

Online publication date: Tue, 16-Jun-2009

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