Here a method, there a method, everywhere many methods. What should a laboratory do to validate an assay for the detection of botulinum neurotoxins? Online publication date: Tue, 16-Jun-2009
by Shashi K. Sharma, Shuowei Cai, Bal Ram Singh
The Botulinum J. (TBJ), Vol. 1, No. 2, 2008
Abstract: Over the past decade, a plethora of new detection methods for Clostridium botulinum Toxins (BoNTs) have been introduced into the bioresearch and bio-defense communities. These methods are on the promise that the detection of BoNTs would be comparable with the mouse bioassay. Furthermore, these methods would be leveraged as a high-throughput system that would identify contaminants more quickly for counter-terrorism purposes. But, few truly novel detection methods have made significant progress. For new advances, challenges, limitations and strategies in the detection, a comprehensive validation strategy is a means to garner equal attention for the successful development of a detection method.
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