Here a method, there a method, everywhere many methods. What should a laboratory do to validate an assay for the detection of botulinum neurotoxins?
by Shashi K. Sharma, Shuowei Cai, Bal Ram Singh
The Botulinum J. (TBJ), Vol. 1, No. 2, 2008

Abstract: Over the past decade, a plethora of new detection methods for Clostridium botulinum Toxins (BoNTs) have been introduced into the bioresearch and bio-defense communities. These methods are on the promise that the detection of BoNTs would be comparable with the mouse bioassay. Furthermore, these methods would be leveraged as a high-throughput system that would identify contaminants more quickly for counter-terrorism purposes. But, few truly novel detection methods have made significant progress. For new advances, challenges, limitations and strategies in the detection, a comprehensive validation strategy is a means to garner equal attention for the successful development of a detection method.

Online publication date: Tue, 16-Jun-2009

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