DNA-protein crosslinks induced by formaldehyde and its repair process
by Wei Zhao, Guangyin Peng, Xu Yang
International Journal of Environment and Pollution (IJEP), Vol. 37, No. 2/3, 2009

Abstract: KCL-SDS assay was used to explore DNA-Protein Crosslinks (DPC) effect induced by formaldehyde (FA) and the repair. Gaseous FA could cause DPC at concentrations as 1.0 mg m⁻³ and 3.0 mg m⁻³ (p < 0.01), which was removed within 12 h. Meanwhile, in vitro studies showed that 75 µmol L⁻¹ liquid FA could significantly induce DPC in HepG2 cells, and was removed after 18 h and 24 h. These results suggested that FA could induce DPC at relatively high concentrations, and removing of DPC in vivo required shorter time than that in vitro.

Online publication date: Wed, 13-May-2009

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