Study of microarray time series data based on Forward-Backward Linear Prediction and Singular Value Decomposition
by Miew Keen Choong, David Levy, Hong Yan
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 3, No. 2, 2009

Abstract: We propose a method to analyse the periodicities of gene expression profiles based on the spectral domain approach. Our spectral reconstruction method outperforms three other recently proposed methods, which do not require any prior knowledge. It is proven that an alternative method for studying cell-cycle regulation is possible even where very little prior knowledge is available. We also investigate the potential of combining signals with similar frequency components to form an overdetermined system of equations, and use least squares solution to estimate the spectral frequency. Results show that this new method is able to estimate the peak frequency more accurately.

Online publication date: Fri, 01-May-2009

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