A proposition for single molecule DNA sequencing through a nanopore entropic trap Online publication date: Tue, 03-Feb-2009
by Stephen J. Sowerby, George B. Petersen
International Journal of Nanotechnology (IJNT), Vol. 6, No. 3/4, 2009
Abstract: We propose that a DNA entropic trap constructed from a single resizable nanopore could be tuned in real time to capture a single-stranded polynucleotide. With a nanopore of sufficient discriminatory capability, the trapped polynucleotide will be immobilised within the corrugational trough of an inter-nucleotide separation and the prolonged dwell time will enable scrutiny of the nucleotide composition by extended measurement of the resistive pulse signal. The nanopore will be tuned to facilitate single nucleotide translocation, allowing for the processive examination of consecutive nucleotides.
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nanotechnology (IJNT):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com