A divide-and-conquer strategy to solve the out-of-memory problem of processing thousands of Affymetrix microarrays
by Chia-Ju Lee, Dong Fu, Pan Du, Hongmei Jiang, Simon M. Lin, Warren Kibbe
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 1, No. 4, 2008

Abstract: Out-of-memory problem was frequently encountered when processing thousands of CEL files using Bioconductor. We propose a divide-and-conquer strategy combined with randomised resampling to solve this problem. The CAMDA 2007 META-analysis data set which contains 5896 CEL files was used to test the approach on a typical commodity computer cluster by running established pre-processing algorithms for Affymetrix arrays in the Bioconductor package. The results were validated against a golden standard obtained by using a supercomputer. In addition to the performance improvement, the general divide-and-conquer strategy can be applied to any other normalisation algorithms without modifying the underlying implementation.

Online publication date: Mon, 22-Dec-2008

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