The novel mechanism of metastasis inhibition by low-dose whole-body irradiation with gamma-rays
by Yasuhiro Ohshima, Mitsutoshi Tsukimoto, Shuji Kojima
International Journal of Low Radiation (IJLR), Vol. 5, No. 2, 2008

Abstract: The influence of repeated 0.5 Gy whole-body gamma-ray irradiation on tumour metastasis was examined from the standpoint of tumour invasion in the B16 melanoma pulmonary metastasis model in mice. We confirmed that 0.5 Gy whole-body gamma-ray irradiation (four doses over two weeks) significantly suppressed colony formation in the lungs. In the lung tissue 24 h after irradiation, both the level of matrix metalloproteinase-2 (MMP-2) protein and its activity were significantly decreased. We also found that the activity of MMP-9 was significantly decreased in the lungs after the irradiation. Furthermore, both the expression and activity of tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) were increased after the irradiation. These results indicate that a decrease of these MMPs and an increase of TIMP-2 would be involved in the suppression of tumour metastasis by repeated 0.5-Gy gamma irradiation.

Online publication date: Fri, 15-Aug-2008

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Low Radiation (IJLR):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com