Analysing formal models of genetic regulatory networks with delays
by Jamil Ahmad, Olivier Roux, Gilles Bernot, Jean-Paul Comet, Adrien Richard
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 4, No. 3, 2008

Abstract: In this paper, we propose a refinement of the modelling of biological regulatory networks based on the discrete approach of Rene Thomas. We refine and automatise the use of delays of activation/inhibition in order to specify which variable is more quickly affected by a change of its regulators. The formalism of linear hybrid automata is well suited to allow such refinement. We then use HyTech for two purposes: to find automatically all paths from a specified initial state to another one; to synthesise constraints on the delay parameters in order to follow any specific path.

Online publication date: Thu, 17-Jul-2008

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