Decoding algorithms in pooling designs with inhibitors and error-tolerance Online publication date: Wed, 09-May-2007
by My T. Thai, David MacCallum, Ping Deng, Weili Wu
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 3, No. 2, 2007
Abstract: Pooling designs are used in DNA library screening to efficiently distinguish positive from negative clones, which is fundamental for studying gene functions and many other biological applications. One challenge is to design decoding algorithms for determining whether a clone is positive based on the test outcomes and a binary matrix representing the pools. This is more difficult in practice due to errors in biological experiments. More challenging still is a third category of clones called 'inhibitors' whose effect is to neutralise positives. We present a novel decoding algorithm identifying all positive clones in the presence of inhibitors and experimental errors.
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