Effect of sodium hyaluronate-based nanoprobe in rehabilitation of tendon injury and tendon adhesion Online publication date: Mon, 13-Feb-2023
by Siqi Lv
International Journal of Nanotechnology (IJNT), Vol. 19, No. 6/7/8/9/10/11, 2022
Abstract: This study aimed to investigate the role of nanoprobe fibres mediated by sodium hyaluronate in rehabilitation of tendon injury and adhesion. Hyaluronic acid (HA) nanoprobes (HA/NPs) were prepared by solvent removal method and loaded into poly ε-caprolactone (PCL) fibres to prepare nanofibre membranes with different orientations. 60 Sprague-Dawley (SD) rats were divided into control group, model group, aPCL group, rPCL group, aPCL+HA group, and rPCL+HA group according to different materials, so as to compare tenomodulin (TNMD) and scleraxis (SCX) expression levels in tendon tissues of each group. Results showed that cumulative release of bFGF in vitro of aPCL+HA was twice that of rPCL+HA (P < 0.05); average tensile strength of aPCL+HA was higher than that of rPCL+HA (P < 0.01); SCX and TNMD expressions were higher than those of control group (P < 0.01). Therefore, aPCL+HA nanoprobe fibre mediated by sodium hyaluronate had good tendon repair ability in tendon adhesion rehabilitation.
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nanotechnology (IJNT):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com
Our Blog 
Follow us on Twitter 
Visit us on Facebook