Mechanism of action of the Wuzi Yanzong prescription to treat asthenozoospermia based on network pharmacology and molecular docking
by Xinyu Zhai; Minyue Tan; Zhong Wan; Yi Ding; Minyao Ge; Dongliang Xu
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 26, No. 3/4, 2021

Abstract: The current study attempted to identify the action target and related signal pathways of the Wuzi Yanzong prescription for the treatment of asthenozoospermia (AZS) by using network pharmacology and molecular docking. We identified 72 active components in five traditional Chinese medications and screened their 216 corresponding targets. We identified 147 target AZS-related genes after intersecting the results from both screenings. Our results suggest that AKT1, interleukin 6 (IL6), vascular endothelial growth factor A (VEGFA), caspase 3 (CASP3), JUN, MYC, epidermal growth factor receptor (EGFR), epidermal growth factor (EGF), oestrogen receptor 1 (ESR1), and mitogen-activated protein kinase 8 (MAPK8) may be the core targets of the Wuzi Yanzong prescription for AZS. We found 1023 gene ontology (GO) functional enrichment analysis core targets, including 965 biological processes (BP), 15 cell composition (CC), and 43 molecular function (MF) targets. After screening the Kyoto Encyclopaedia of Genes and Genomes (KEGG) screening, we obtained 103 AZS-related pathways. The Wuzi Yanzong prescription acts mainly on AKT1, IL6, VEGFA, CASP3 and other targets to regulate mitogen-activated protein kinases (MAPK), focal adhesion, Hypoxia-inducible factor 1 (HIF-1), tumour necrosis factor (TNF) and other signal pathways to improve AZS.

Online publication date: Tue, 08-Nov-2022

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Data Mining and Bioinformatics (IJDMB):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com