Production calculations of ¹⁷⁷Lu as a no carrier added radionuclide in Tehran Research Reactor
by Nafise Salek; Sara Vosoughi; Ali Bahrami Samani
International Journal of Nuclear Energy Science and Technology (IJNEST), Vol. 15, No. 2, 2021

Abstract: : Owing to the suitable nuclear decay characteristics, ¹⁷⁷Lu is an attractive radionuclide for various therapeutic applications. The non-carrier added form of ¹⁷⁷Lu has drawn attentions because of its high specific activity needed in radio-labelling studies. In this study, the radioactivities of ¹⁷⁷Lu and other impurities are calculated by MATLAB software. The experimental studies were followed by irradiating of enriched [¹⁷⁶Y]Yb₂O₃ target in TRR in thermal neutron fluxes of 4 × 10¹³ to 1×10¹⁴ n.cm⁻²s⁻¹ for 5-14 days. The separation of ¹⁷⁷Lu from Yb target was performed by EXC and ELM. The results showed there is a good compatibility between the measured values and the results of the theoretical calculations (3% error). Furthermore, by producing ¹⁷⁷Lu in form of NCA, its specific activity increased 104 times with longer shelf-life. The result approved the possibility of production NCA-¹⁷⁷Lu in TRR by suitable specific activity which can be used for antibody and peptide therapy.

Online publication date: Tue, 10-May-2022

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