Effects of collagen-based nano-biomaterials on the health of lower limb joint sports
by Chengguo Chen; Yameng Liu; Peng Liu
International Journal of Nanotechnology (IJNT), Vol. 18, No. 1/2/3/4, 2021

Abstract: This paper mainly studies the related properties of PHBHOx as an osteochondral integrated tissue engineering scaffold, as well as the extraction and in vitro culture of bone marrow mesenchymal stem cells and the composite culture with scaffolds. In order to study the effect of PHBHOx/collagen integrated osteochondral scaffold on the recovery of osteochondral faults in knee weight-bearing area, three experimental groups were established and animal models were established. An external fixator was placed on the right femur in all experimental animals. The scaffold + cell group was implanted with a scaffold-BMSCs complex; the simple scaffold group was implanted with a PHBHOx/collagen integrated osteochondral scaffold after modelling; the control group was not provided with a scaffold. The animals were grossly observed at 4 weeks, 8 weeks, and 12 weeks after operation. ICRS cartilage repair gross score, HE staining, safranin O staining, and type B collagen immunohistochemical staining were used. Score, and make a comprehensive assessment of the repair effect of osteochondral defect. Collagen-based bone material has a good effect in repairing articular cartilage damage, and can reduce the occurrence of complications. The mechanism may be related to effective relief and improvement of joint function.

Online publication date: Tue, 13-Apr-2021

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nanotechnology (IJNT):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com