Assessment of drug-drug interactions and its associated factors in patients receiving second-line antitubercular drugs (MDR TB/XDR TB) in a tertiary care hospital in eastern India
by P. Ansuman Abhisek; Priti Das; Shweta Supriya Pradhan; Geetanjali Panda; Srikanta Mohanty
International Journal of Medical Engineering and Informatics (IJMEI), Vol. 12, No. 3, 2020

Abstract: This was a prospective, observational study conducted to assess prevalence of different spectrum of DDIs in MR/XDR TB patients by analyzing 42 prescriptions. DDIs were analysed by softwares like Lexicomp, Micromedex, and Drugs.com, Medscape.com. Only interactions of major/moderate severity were included in the potential DDIs analysis. Quantitative assessments were compared using one way ANOVA. Qualitative assessment of software was done manually by mere observation. Patients received 12.52 (±4.04) drugs during their total treatment period. Among 467 interactions observed, 34.04% were major, 50.10% moderate. All the patients had at least one potential DDI and 92.85% were exposed to at least one major potential DDI. Among the 'risk rating avoid combinations' (X) were 7.28%, 'modify regimen' (D) were 15.04%. Most DDIs were of moderate severity (50.10%) and the possible mechanism of DDI found was of pharmacodynamic in nature (49.76%). This study assists in understanding the utility of computer software-based programs to assess potential DDIs and the factors associated with them.

Online publication date: Mon, 04-May-2020

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Medical Engineering and Informatics (IJMEI):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com