Ortholog detection: pathway to comparative genomics Online publication date: Fri, 24-Apr-2020
by Manpreet Singh; Shaifu Gupta
International Journal of Computational Intelligence in Bioinformatics and Systems Biology (IJCIBSB), Vol. 2, No. 1, 2020
Abstract: Accurate detection of orthologs is a key aspect of comparative genomics. Orthologs can be used to predict the function of newly sequenced genes from the model organisms as they retain the same biological function through the path of evolution. In this paper, we describe different methods available for the detection of orthologs. Different computational methods comprising of phylogenetic as well as pair-wise comparison are discussed and compared. Some other methods based on synteny and protein network comparisons are also included in the paper. The study shows that phylogenetic methods of detecting orthologs are comparatively accurate and reliable than the pair-wise graph based methods but computationally more intensive and slow. These should be used only when sufficient computational power is available for operation. On the other hand, pair-wise approaches are fast and can handle large amounts of data. Synteny based methods also form a good candidate for the detection of orthologs.
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Computational Intelligence in Bioinformatics and Systems Biology (IJCIBSB):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com
Our Blog 
Follow us on Twitter 
Visit us on Facebook