Computational study of drug delivery in tumorous human airways Online publication date: Fri, 22-Nov-2019
by Vivek Kumar Srivastav; Akshoy Ranjan Paul; Anuj Jain
International Journal of Computing Science and Mathematics (IJCSM), Vol. 10, No. 5, 2019
Abstract: There is increasing interest in the research of direct drug delivery in respiratory tract because of its attractiveness to produce greater therapeutic benefits for the treatment of pulmonary diseases and systemic diseases. In the present study, airway respiratory model was constructed from CT scan images. A tumour was artificially created in the trachea of the respiratory model for the CFD simulation of the aerosol-particles transport and its deposition on the tumour. The CFD simulation was carried out for three air inhalation flow rates: 20, 40 and 60 L/min, and three particle sizes of 1, 5 and 10 µm to determine the effect of these parameters on the deposition efficiency of the particles on the tumour. The results show that the maximum aerosol deposition on the tumour occurs at 60 L/min inhalation rate for 5-10 µm aerosol-particles size. The findings will be useful to maximise therapeutic benefits of respiratory drug delivery.
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Computing Science and Mathematics (IJCSM):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email subs@inderscience.com
Our Blog 
Follow us on Twitter 
Visit us on Facebook