Integral genotype structure, individual radiosensitivity and health status of personnel chronically exposed to gamma and neutron irradiation
by I.B. Korzeneva, T.V. Malinina, S.I. Zaichkina, Y.E. Dubrova, B.A. Kalabushkin, E.N. Kalacheva, V.F. Samsonova, R.T. Shishova
International Journal of Low Radiation (IJLR), Vol. 3, No. 1, 2006

Abstract: Preliminary data on the effects of genotype and individual radiosensitivity on health status of the group of nuclear reactors' workers from Russian Federal Nuclear Center (RFNC-VNIIEF), Sarov, chronically exposed to gamma and neutron irradiation, are presented. Within this cohort of 75 men, 10 polymorphic loci were typed and the frequency of micronuclei was analysed. The analysis of blood samples irradiated ex-vivo did not reveal significant correlation between the occupational dose and MN induction, therefore indicating the lack of adaptation (hormesis) or increased radiosensitivity within this cohort. The analysis of association between genotypes and morbidity revealed: (1) higher incidence of endocrine diseases among homozygotes EsD 2-2 and Gc 1-1; (2) elevated frequency of urological disorders among homozygotes Gc 1-1; (3) elevated incidence of benign (non-malignant) tumors among homozygotes Gc 2-2 and also GLO 2-2, EsD 1-2 or 2-2, showing differences in the frequencies of spontaneous and radiation-induced MN; (4) elevated incidence of cardio-vascular diseases among homozygotes ACP 1-1 and EsD 1-2 or 2-2, also mediated by the differences in MN frequency. The contribution of genotype and individual radiosensitivity (MN test) to the health status of occupationally exposed individuals will be discussed.

Online publication date: Thu, 08-Jun-2006

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Low Radiation (IJLR):
Login with your Inderscience username and password:

Username:        Password:          Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com