Article Abstract

	Title:	Labelling of albumin microspheres with 188Re: a possible agent for radiotherapy
	Author:	Virginia Nazarica Borza, Elena Neacsu, Catalina Mihaela Barna, Nicoleta Popescu-Pogrion, Ionel Mercioniu, Cristina Lavinia Nistor
	Address:	'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' 'Horia Hulubei' National Institute of R&D for Physics and Nuclear Engineering, IFIN-HH, 407 Atomistilor Street, Bucharest – Magurele, P.O. Box MG-6, code 077125, Romania. ' National Institute of Materials Physics, 105 bis Atomistilor Street, Bucharest – Magurele, P.O. Box MG-7, code 077125, Romania. ' National Institute of Materials Physics, 105 bis Atomistilor Street, Bucharest – Magurele, P.O. Box MG-7, code 077125, Romania.' National Research and Development Institute for Chemistry and Petrochemistry, ICECHIM, 202 Independence Street, District 6, CP 35-174, 060021 Bucharest, Romania
	Journal:	International Journal of Nano and Biomaterials 2009 - Vol. 2, No.6  pp. 540 - 546
	Abstract:	Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter 188Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was studied. Under optimised conditions, after 60 min reaction time, at 95°C, the reaction yield was more than 95%. Labelled microspheres were found to be stable in vitro; 43 h after labelling, 87% of 188Re was bound to the microspheres.
	Keywords:	albumin microspheres; labelling methods; 188Re; radiotherapy; endoradiotherapy; tumours; radiolabelling; beta emitters; hepatocellular carcinoma.
	DOI:	10.1504/IJNBM.2009.028342
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