Statistical issues in the analysis of DNA Copy Number Variations
by Nathan E. Wineinger, Richard E. Kennedy, Stephen W. Erickson, Mary K. Wojczynski, Carl E. Bruder, Hemant K. Tiwari
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 1, No. 4, 2008

Abstract: Approaches to assess copy number variation have advanced rapidly and are being incorporated into genetic studies. While the technology exists for CNV genotyping, a further understanding and discussion of how to use the CNV data for association analyses is warranted. We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platform, normalisation of the array data, calling algorithm, and statistical analysis.

Online publication date:: Mon, 22-Dec-2008

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