The full text of this article

 

Proteins localised to human mitochondria show structural element enrichment in their corresponding mRNA
by Jasjit K. Banwait; Kaitlin A. Goettsch; Dhundy R. Bastola
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 9, No. 1/2, 2016

 

Abstract: Mitochondria are the energy power houses in all eukaryotic cells and are frequently implicated in mediating several diseases. The mitochondrial genome in human contains only 13 protein coding genes. However, the advancements in proteomic technologies have demonstrated that over 1000 proteins are localised to mitochondria. Although, the nuclear encoded proteins are suggested to localise in a cell using N-terminal signal peptide, only 27% of these proteins contain such localisation signals. In this study, we analysed all nuclear encoded mitochondrial proteins and report a potential alternative to peptide signal based localisation of mitochondrial proteins. We have successfully developed a computational framework to identify mRNAs with enriched structural localisation features in their 3'-UTR. Using this approach, we were able to further extend the mitochondrial proteome by identifying seven new proteins that were not previously labelled to be localised to mitochondria by Uniprot but the literature supports their involvement in mitochondria-related functions.

Online publication date: Fri, 26-Feb-2016

 

is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

 
Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

 
Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Computational Biology and Drug Design (IJCBDD):
Login with your Inderscience username and password:

 

    Username:        Password:         

Forgotten your password?


 
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

 
If you still need assistance, please email subs@inderscience.com