Revelations in reptilian and avian immunology: a proposed evolutionary selection pressure for truncated immunoglobulin-Y Online publication date: Sat, 10-Jan-2015
by Jonathan Ian Meddings; Leigh Owens; Graham Burgess; Ellen Ariel
International Journal of Immunological Studies (IJIS), Vol. 2, No. 1, 2014
Abstract: We propose for the first time that antibody-dependent enhancement (ADE) of viral infection has served as an evolutionary selection pressure in which species that produce truncated immunoglobulin-Y (IgY) have had a selective advantage. The absence of the Fc region prevents binding of antibody-covered virions to cellular Fc receptors and to complement component C1q, thus preventing ADE by these mechanisms and limiting viral entry to cells. It logically follows that the range of cell types potentially infected would be reduced, slowing the invasive nature of viral infections. We briefly review the structure, function and evolution of IgY, the mechanisms of ADE, discuss how producing truncated immunoglobulins could limit ADE, and how future research can falsify or confirm this hypothesis.
Online publication date: Sat, 10-Jan-2015
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Immunological Studies (IJIS):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email email@example.com