The full text of this article


Mining for representative regions of virus genuses via protein sequences clustering
by Jing-Doo Wang; Yi-Chun Wang
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 9, No. 3, 2014


Abstract: Highly conserved sequences (regions or domains) play an important role in phylogenetic analysis. In this study, a novel approach to extract highly conserved sequences as representative regions for the genuses of viruses via protein sequences clustering is proposed. A representative region of one genus is extracted from one distinctive protein sequence group and appears in all members of that genus; a distinctive feature of a protein sequence group formed by a graph-based clustering method is that the sequences within that group appear in all members of one genus but none of the other genuses. Experimental results showed that there were 64 representative regions belonging to 20 genuses extracted in this study. This study not only creates a methodology to extract highly conserved sequences for phylogenetic analysis across taxa, but also provides the materials for investigating viral taxonomy from a molecular biology point of view, instead of traditional morphology.

Online publication date: Mon, 07-Oct-2013


is only available to individual subscribers or to users at subscribing institutions.

Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Data Mining and Bioinformatics (IJDMB):
Login with your Inderscience username and password:


    Username:        Password:         

Forgotten your password?

Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email