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Multiscale agent-based modelling of ovarian cancer progression under the stimulation of the STAT 3 pathway
by Le Zhang; Yao Xue; Beini Jiang; Costas Strouthos; Zhenfeng Duan; Yukun Wu; Jing Su; Xiaobo Zhou
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 9, No. 3, 2014

 

Abstract: This research is developed to simulate ovarian cancer progression with signal transducers and activators of the transcription 3 (STAT 3) pathway. The main focus is on studying how the STAT 3 pathway affects the cancer cells' biomechanical phenotype under the stimulation of the interleukin-6 (IL-6) cytokine and various well-known microscopic factors. The simulated results agreed with recent experimental evidence that ovarian cancer cells with a stimulated STAT 3 pathway have high survival rates and drug resistance. And we discussed how the IL6 and these well-known microscopic factors impacted the cancer progression.

Online publication date: Mon, 07-Oct-2013

 

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