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Structural and functional features of Streptolysin O
by Ashfaq Ahmad; Ghosia Lutfullah; Roshan Ali
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 7, No. 4, 2011


Abstract: Streptolysin O, a 63 kDa exotoxin coded by slo gene, is a well-characterised thiol-activated cytolysin, which damages cholesterol-containing membranes resulting in disruption and lysis of the target cell. On the basis of homology model and secondary structure analysis, the toxin has four domains of which domain 4 is of particular importance and is directly linked to domain 2 by a glycine linker and remained consistent in initial membrane recognition. Domain 4 reduces the hydrophobic ratio when compared with its template, which would affect the activity of the toxin at low pH.

Online publication date: Mon, 14-Nov-2011


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