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Activated germinal centre B cells undergo directed migration
by Mark J. O'Connor, Anja E. Hauser, Ann M. Haberman, Steven H. Kleinstein
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 5, No. 3, 2011


Abstract: Affinity maturation, the fundamental basis for adaptive immunity, is accomplished through somatic hypermutation of B-cell receptors followed by expansion of rare mutants with higher affinity for the immunising antigen. This process occurs over a period of weeks in unique micro-anatomic sites known as germinal centres. Two-photon microscopy has recently made it possible to track individual cells moving within germinal centres in living animals. Here we apply statistical approaches to test the hypothesis that B-cell motion is random. Our results show that activated B cells move in a directed manner that sharply contrasts with the behaviour of naïve B cells.

Online publication date: Wed, 25-May-2011


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