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microRNA: human disease and development
by Virendra S. Gomase, Akshay N. Parundekar
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 5, No. 5, 2009


Abstract: microRNAs or miRNAs are an abundant class of highly conversed, small non-coding RNAs that present an entirely new theme of post-transcriptional gene regulation. miRNAs play a key role in diverse biological systems, such as virology, embryogenesis, differentiation, inflammation and cancer research. Research showed the importance of these non-coding small RNAs on immune system development and response. It plays important regulatory roles in various metabolic pathways in most eukaryotes. miRNAs are found to be involved in the regulation of immunity, including the development and differentiation of immune cells, antibody production and the inflammatory mediator release.


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