Exploration of homodimer receptor: homodimer protein interactions Online publication date: Tue, 28-Jul-2009
by Julio Vera, Taesoo Kwon, Ulf Schmitz, Walter Kolch, Olaf Wolkenhauer
International Journal of Bioinformatics Research and Applications (IJBRA), Vol. 5, No. 4, 2009
Abstract: Homodimerisation is producing a protein–protein complex composed of two identical molecules. Dimerisation is a phenomenon often occurring in the regulation of biochemical systems like signal transduction pathways. We investigated whether the existence of a homodimer-activated receptor and the activation of homodimer transducers correspond to a more general pattern in cell signalling. We developed a workflow to merge data from the Gene Ontology and the BIND database to produce a list of interactions between homodimer receptors and homodimer proteins. Finally, we found a prevalence of homodimer–homodimer interactions in signalling systems in human cells.
Online publication date: Tue, 28-Jul-2009
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