Thyroxin, glucose, body growth rate and non-protein nitrogen constituents in albino rats treated with excess potassium iodate Online publication date: Sat, 07-Feb-2009
by Maged M. Yassin, Ismail I. Abd El-Aziz, Fayez A. El Mabhouh
International Journal of Food Safety, Nutrition and Public Health (IJFSNPH), Vol. 1, No. 2, 2008
Abstract: The study was aimed to determine median lethal dose (LD50) of potassium iodate and to assess its toxicity in albino rats. The oral LD50 was found to be 752 mg kg−1 body weight. A dose of 1/5 LD50 potassium iodate was then given to animals (n = 36). Control animals (n = 36) received distilled water. Means were compared by independent-samples t-test. Growth rates of experimental animals were decreased, particularly at the first two weeks (27.5 and 24.2%, p = 0.009 and 0.000, respectively). Significant increase in serum thyroxin was observed at the second and third weeks (p = 0.007 and 0.046, respectively). Mean glucose levels were significantly decreased with maximum difference of 26.3% at the fifth week (106.1 ± 4.9 ν 78.2 ± 4.2, p = 0.002). Urea was decreased (max difference = 23.6%, mean = 35.6 ± 1.8 ν 27.2 ± 1.7, p = 0.007) whereas uric acid and creatinine were increased (max difference = 25.4%, mean = 1.77 ± 0.08 ν 2.22 ± 0.12, p = 0.011 and 19.6%, 0.56 ± 0.03 ν 0.67 ± 0.03, p = 0.022, respectively).
Online publication date: Sat, 07-Feb-2009
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Food Safety, Nutrition and Public Health (IJFSNPH):
Login with your Inderscience username and password:
Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.
If you still need assistance, please email firstname.lastname@example.org