Title: Statistical evaluation of NMR backbone resonance assignment

Authors: Guohui Lin, Xiang Wan, Theodore Tegos, Yingshu Li

Addresses: Department of Computing Science, University of Alberta, Edmonton, Alberta T6G 2E8, Canada. ' Department of Computing Science, University of Alberta, Edmonton, Alberta T6G 2E8, Canada. ' Department of Computing Science, University of Alberta, Edmonton, Alberta T6G 2E8, Canada. ' Department of Computer Science, Georgia State University, P.O. Box 3994, Atlanta, GA 30302, USA

Abstract: This paper proposes a novel statistical evaluation model for automated protein NMR sequential resonance assignment. It can be bound to any assignment program and provides confidences for the whole output assignment and each individual mapping. A simulation study on a set of four proteins shows that the statistical evaluation results are informative.

Keywords: protein structure determination; NMR sequential resonance assignment; statistical evaluation; normal distribution; bioinformatics; simulation; nuclear magnetic resonance spectroscopy.

DOI: 10.1504/IJBRA.2006.009765

International Journal of Bioinformatics Research and Applications, 2006 Vol.2 No.2, pp.147 - 160

Published online: 09 May 2006 *

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