Title: Neural signature of event-related N200 and P300 modulation in parietal lobe during human response inhibition

Authors: Rupesh Kumar Chikara; Oleksii Komarov; Li-Wei Ko

Addresses: Department of Biological Science and Technology and Brain Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan ' Institute of Molecular Medicine and Bioengineering and Brain Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan ' Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu 30010, Taiwan

Abstract: Response inhibition is a process of motor control and related to the suppression of the action. The role of inhibition in many studies remains an issue of debate, most researchers nevertheless agree that some sort of inhibition mechanism is involved in the deliberate cessation of a motor response. Therefore, stop-signal task has been designed to investigate the response inhibition. Other aspects also encourage the importance of this study, because deficits in response inhibition is an essence in a variety of neurological disorders such as schizophrenia and attention deficit hyperactivity disorder (ADHD). The aim of present study is to examine the brain modulation of left and right-hand response inhibitions with electroencephalography (EEG). The results indicate response inhibition related neural signatures including the N200 and P300 waves in the frontal, central and parietal regions. This work accomplishes that the independent nature of the inhibitory control of the left-and right-hand.

Keywords: EEG; electroencephalography; stop-signal task; response inhibition; ERP; event-related potentials; N200; P300.

DOI: 10.1504/IJCBDD.2018.090842

International Journal of Computational Biology and Drug Design, 2018 Vol.11 No.1/2, pp.171 - 182

Received: 09 Mar 2017
Accepted: 16 Sep 2017
Published online: 28 Mar 2018 *

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