Title: Comparison of xenopericardial patches of different origin and type of fixation implemented for TAVI

Authors: Evgeny A. Ovcharenko; Kirill U. Klyshnikov; Arseniy E. Yuzhalin; Gennady V. Savrasov; Tatiana V. Glushkova; Georgy U. Vasukov; Dmitry V. Nushtaev; Yulia A. Kudryavtseva; Leonid S. Barbarash

Addresses: Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd. 6, Kemerovo 650002, Russia ' Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd. 6, Kemerovo 650002, Russia ' Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Roosevelt Drive, Oxford, OX3 7DQ, UK ' Department of Biomedical Technologies, Bauman Moscow State Technical University, Baumanskaya 2-ya Str. 5, Moscow 105005, Russia ' Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd. 6, Kemerovo 650002, Russia ' Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd. 6, Kemerovo 650002, Russia ' "TESIS" Limited Liability Company, Yunnatov Str. 18, Moscow 127083, Russia ' Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd. 6, Kemerovo 650002, Russia ' Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Blvd. 6, Kemerovo 650002, Russia

Abstract: The study analysed the mechanical properties by uniaxial test of porcine and bovine pericardial specimens, stabilised with the glutaraldehyde or with the ethylene glycol diglycidyl ether. Also the paper describes, the ability of these samples compressed to 18 Fr with via the finite element method. Analysis of the properties of the biomaterial demonstrated a low strength for all types of porcine pericardium with the lowest value for the EGDE-treated pericardium (2.75 N). The lowest stress-strain state during the simulation of the leaflet crimping was observed in experimental porcine pericardial patch with the minimum principal logarithmic strain of 0.32 m/m. The results of this study allow us to make conclusions about the desirability of the use of porcine pericardium treated with glutaraldehyde for transcatheter aortic valve prostheses.

Keywords: xenopericardium; leaflets; uniaxial test; biomaterial; porcine; bovine; finite element analysis; FEA.

DOI: 10.1504/IJBET.2017.086551

International Journal of Biomedical Engineering and Technology, 2017 Vol.25 No.1, pp.44 - 59

Received: 11 Apr 2016
Accepted: 27 Jul 2016
Published online: 12 Sep 2017 *

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