Title: In vitro evaluation of cell compatibility and hemocompatibility of a Cu-bearing titanium alloy

Authors: Zheng Ma; Mengyu Yao; Ling Ren; Mei Li; Yu Zhang; Ke Yang

Addresses: Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China; Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, China ' Orthopedic Department, Guangzhou Military General Hospital, Guangzhou, China ' Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China ' Orthopedic Department, Guangzhou Military General Hospital, Guangzhou, China ' Orthopedic Department, Guangzhou Military General Hospital, Guangzhou, China ' Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China

Abstract: A new antibacterial copper (Cu)-bearing titanium alloy, Ti-6Al-4V-5Cu alloy is fabricated by introducing Cu into conventional titanium alloy. However, Cu is a double-edged sword and excessive Cu ions release may lead to biological problems. In this study, considering the potential toxicity of Cu release from Ti-6Al-4V-5Cu alloy, the cytocompatibility, hemocompatibility and electrochemical corrosion behaviour of the alloy are systematically studied. The results indicate that MC3T3-E1 cells grew well on surface of Ti-6Al-4V-5Cu alloy and the relative growth rate is higher than 75%, showing good cytocompatibility. Platelets on surface of Ti-6Al-4V-5Cu alloy are less and fully spread, and the hemolysis ratio is 0.6%, showing good hemocompatibility of the alloy. Ti-6Al-4V-5Cu alloy shows great potentials in clinical application with strong antibacterial performance, good cytocompatibility and hemocompatibility.

Keywords: titanium alloys; antibacterial copper; copper addition; cytocompatibility; hemecompatibility; in vitro evaluation; cell compatibility; toxicity; electrochemical corrosion; platelets; hemolysis ratio; medical implants; biocompatibility; corrosion resistance; biomaterials; bioengineering.

DOI: 10.1504/IJCMSSE.2016.081686

International Journal of Computational Materials Science and Surface Engineering, 2016 Vol.6 No.3/4, pp.228 - 243

Received: 12 Oct 2015
Accepted: 18 Mar 2016
Published online: 20 Jan 2017 *

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