Title: Analysis of collagen fibres on remodelling

Authors: C. Pon Selvi; R. Kalpana; K. Vaishnavi; R. Deepachitra; T.P. Sastry

Addresses: Department of Biomedical Engineering, Rajalakshmi Engineering College, Chennai, India ' Department of Biomedical Engineering, Rajalakshmi Engineering College, Chennai, India ' Department of Biomedical Engineering, Rajalakshmi Engineering College, Chennai, India ' Department of Bioproducts, Central Leather Research Institute (CLRI), Chennai, India ' Department of Bioproducts, Central Leather Research Institute (CLRI), Chennai, India

Abstract: Remodelling of biological tissue is an important evolutionary process in any organ which has an increasing field of research focus during recent years. Collagen being one of the load bearing protein takes the responsibility of repair and regeneration on application of external mechanical load. Presented in this paper is a study on its remodelling through a mathematical model in the aim of analysing load bearing capability of collagen fibres. Von Mises distribution used to model the dispersion and strain energy density function (SEDF) is used to model the reorientation process. The results demonstrate the reorientation process in response to the mechanical stimuli and its value assessment for complete re-alignment. The results thus obtained through modelling are experimentally validated by performing tensile strength test on the extracted collagen from animal waste. This kind of knowledge about the behaviour of collagen on different condition could be one useful information for physicians while performing/recommending physiotherapy.

Keywords: collagen fibres; remodelling; Von Mises distribution; reorientation; strain energy density function; SEDF; mathematical modelling; load bearing capability; load bearing proteins; tensile strength; physiotherapy.

DOI: 10.1504/IJMEI.2016.073663

International Journal of Medical Engineering and Informatics, 2016 Vol.8 No.1, pp.14 - 26

Published online: 15 Dec 2015 *

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