Title: Comparison of neutrophil function in diabetic and non-diabetic with generalised chronic and aggressive periodontitis: an in vitro study

Authors: Sunil Pendor; K. Malathi; Kiran Kumar Ganji

Addresses: Department of Periodontics, Sharad Pawar Dental College, Sawangi Meghe, Wardha 442001, India ' Department of Periodontics, Government Dental College, Chennai 600003, India ' Department of Periodontics, Sharad Pawar Dental College, Sawangi Meghe, Wardha 442001, India

Abstract: Background: Epidemiological studies have shown the risk for periodontitis in diabetes mellitus patient is greater than non-diabetes. Aim: To assess neutrophil function, i.e., Chemotaxis, Phagocytosis and Specific Granule release in Diabetic and Non-Diabetic patients with Generalised Chronic and aggressive periodontitis patients. Materials and Method: 60 patients were selected to participate in the study which was divided into four groups. Blood samples from 60 patients were collected after drawing 5 ml peripheral venous blood and then various assays were carried out to assess the neutrophil functions mentioned above. Results: It was found that defective chemotaxis present in diabetic and in generalised aggressive periodontitis patients. Defective phagocytosis was observed in diabetic and generalised aggressive and chronic periodontitis. And defective specific granule release was observed only in diabetic patient when compared with healthy controls. Conclusion: This study has proved that there is association between neutrophil dysfunction and severity of periodontal diseases.

Keywords: neutrophil function; chronic periodontitis; aggressive periodontitis; diabetes mellitus; diabetic patients; non-diabetic patients; chronic periodontitis; chemotaxis; phagocytosis; specific granule release; periodontal diseases.

DOI: 10.1504/IJIS.2014.066841

International Journal of Immunological Studies, 2014 Vol.2 No.1, pp.1 - 15

Received: 05 Feb 2013
Accepted: 14 Oct 2013
Published online: 10 Jan 2015 *

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